Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …

Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving
interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2, 3 …

Aims: Depression and other psychiatric disorders are frequent in HCV-infected patients,
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …

The currently recommended therapy for chronic hepatitis C (HCV) is a combination of
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …

Indoleamine 2, 3‐dioxygenase (IDO), a key enzyme of tryptophan (TRP) metabolism, is
induced in various tissues of patients with bacterial and viral infection or with neoplastic …

There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …

Background Risk of depression and suicide in patients on interferon remains also after the
treatment, the pathogenesis of which is still unclear. We aimed to determine the influence of …

BACKGROUND & AIMS: Interferon-associated depression is a frequent side effect of
antiviral therapy for chronic hepatitis C. The aim of the present study was to investigate the …

Background Interferon-alpha (IFN α)-associated mood disorder is a major complication of
treatment for chronic hepatitis C. Method The authors report on three patients infected with …

BACKGROUND: Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme,
indoleamine-2, 3-dioxygenase, during immune activation may contribute to development of …