The type I interferon pathway plays a critical role in both host defense and tolerance against
viral infection and thus requires refined regulatory mechanisms. RIPK3-mediated …

Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We
report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and …

RIPK3 was reported to play an important role in the protection against influenza A virus (IAV)
in vivo. Here we show that the requirement of RIPK3 for protection against IAV infection in …

Type I interferons (IFNs) are essential innate immune proteins that maintain tissue
homeostasis through tonic expression and can be upregulated to drive antiviral resistance …

The innate immune response is a central element of the initial defense against bacterial and
viral pathogens. Macrophages are key innate immune cells that upon encountering …

Innate immune sensing of influenza A virus (IAV) induces activation of various immune
effector mechanisms, including the nucleotide and oligomerization domain, leucine-rich …

Acute respiratory infections caused by influenza A virus (IAV) spread widely and lead to
substantial morbidity and mortality. Host cell induction of type I interferon (IFN-I) plays a …

Interferon-stimulated genes (ISGs) create multiple lines of defense against viral infection.
Here, we show that interferon-induced protein 35 (IFI35) inhibits swine (H3N2) influenza …

Receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3) are homologous serine–
threonine kinases that were recognized for their roles in directing programmed necrotic cell …

Receptor interacting protein kinase 1 (RIPK1) participates in several cell signaling
complexes that promote cell activation and cell death. Stimulation of RIPK1 in the absence …