Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p

H Liu, H Guan, X Tan, Y Jiang, F Li… - Free radical biology and …, 2022 - Elsevier
Quercetin and EGCG exhibit anti-diabetic and anti-obesity activities, however, their
interactive effects in anti-diabetic/anti-obesity actions and underlying mechanisms remain …

Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high-fat diets

Y Tan, CC Tam, M Rolston, P Alves, L Chen, S Meng… - Antioxidants, 2021 - mdpi.com
Quercetin is a flavonoid that has been shown to have health-promoting capacities due to its
potent antioxidant activity. However, the effect of chronic intake of quercetin on the gut …

Quercetin impacts expression of metabolism-and obesity-associated genes in SGBS adipocytes

A Leiherer, K Stoemmer, A Muendlein, CH Saely… - Nutrients, 2016 - mdpi.com
Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a
hypoxic environment in adipose tissue which leads to a profound change of gene …

Quercetin Preserves β‐Cell Mass and Function in Fructose‐Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation

JM Li, W Wang, CY Fan, MX Wang… - Evidence‐Based …, 2013 - Wiley Online Library
Fructose‐induced hyperinsulinemia is associated with insulin compensative secretion and
predicts the onset of type 2 diabetes. In this study, we investigated the preservation of dietary …

Quercetin and quercetin‐3‐O‐glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species …

XD Guo, DY Zhang, XJ Gao, J Parry… - Molecular nutrition & …, 2013 - Wiley Online Library
Scope Quercetin represents antioxidative/antiinflammatory flavonoids widely distributed in
the human diet. Quercetin is efficiently metabolized during absorption to quercetin‐3‐O …

Prevention effect of quercetin and its glycosides on obesity and hyperglycemia through activating AMPKα in high-fat diet-fed ICR mice

H Jiang, Y Horiuchi, KY Hironao, T Kitakaze… - Journal of Clinical …, 2020 - jstage.jst.go.jp
抄録 Quercetin and its glycosides possess various health beneficial functions, but
comparative study of them on energy metabolism in different tissues are not well studied. In …

Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice

L Shao, K Liu, F Huang, X Guo, M Wang, B Liu - Inflammation, 2013 - Springer
Flavonoids are polyphenolic compounds ubiquitous in plants. Quercetin, luteolin, and
epigallocatechin gallate (EGCG) are flavonoids with a number of biochemical and cellular …

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

C Sampath, MR Rashid, S Sang, M Ahmedna - Food Chemistry, 2017 - Elsevier
Prolonged hyperglycemia activates the formation of advanced glycation end-products
(AGEs). Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the …

Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs

J Zhao, Y Sun, C Yuan, T Li, Y Liang, H Zou, J Zhang… - Food & Function, 2023 - pubs.rsc.org
As a natural pigment in food, quercetin possesses multiple biological activities and plays a
crucial role in regulating metabolic syndrome. Herein, we aim to explore the potential …

(−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II …

X Li, S Li, M Chen, J Wang, B Xie, Z Sun - Food & function, 2018 - pubs.rsc.org
As a major component of green tea,(−)-epigallocatechin-3-gallate (EGCG) has attracted
interest from scientists owing to its potential to combat a variety of human diseases including …