Understanding of the factors governing immune responses in cancer remains incomplete,
limiting patient benefit. In this study, we used mass cytometry to define the systemic immune …

Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor …

Immunotherapies have achieved remarkable successes in the treatment of cancer, but major
challenges remain,. An inherent weakness of current treatment approaches is that …

Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable
responses in a subset of cancer patients, despite advanced disease. However, the …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …

The clinical successes in immunotherapy have been both astounding and at the same time
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …

Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Most tumor cells express antigens that can mediate recognition by host CD8+ T cells.
Cancers that are detected clinically must have evaded antitumor immune responses to grow …

Purpose: Throughout their development, tumors are challenged by the immune system, and
they acquire features to evade its surveillance. A systematic view of these traits, which shed …

On the basis of data published in Nature Medicine, the research groups of Zitvogel and
Kroemer have hypothesized that the adaptive immune system dictates the therapeutic …