There is growing evidence for a role of the hemopoietic microenvironment in the
pathophysiology of myelodysplastic syndromes (MDS). Effects of various cytokines on the …

Many cell types in the bone marrow microenvironment affect HSC function and contribute to
malignancy. Further understanding how HSCs are regulated by the microenvironment has …

Highlights•The ECM supports the HSC-supportive function of the bone marrow
microenvironment. microenvironment•The ECM provides a scaffold and serves as a source …

Various cell types cooperate to create a highly organized and dynamic micro‐environmental
niche in the bone marrow. Over the past several years, the field has increasingly recognized …

Hematopoietic stem and progenitor cells located in the bone marrow lay the foundation for
multiple lineages of mature hematologic cells. Bone marrow niches are architecturally …

In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might
arise from pressure exerted by the neoplastic clone in shaping a supportive …

The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells
(HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into …

Self-renewing hematopoietic stem cells and their progeny, lineage-specific downstream
progenitors, maintain steady-state hematopoiesis in the bone marrow (BM). Accumulating …

Adult hematopoietic stem cells (HSCs) and progenitors (HPCs) reside in the bone marrow, a
highly orchestrated architecture. In the bone marrow, the process of how HSCs exert self …

The main function of the microenvironment in the bone marrow (BM) is to provide signals
that regulate and support the production of the billions of blood cells necessary to maintain …