Cystic fibrosis, the most commonly inherited lethal pulmonary disorder in Caucasians, is
caused by mutations in the cystic fibrosis transmembrane conductance regulator gene …

The physiological components that contribute to cystic fibrosis (CF) lung disease are steadily
being elucidated. Gene therapy could potentially correct these defects. CFTR-null pigs …

Cystic fibrosis (CF) is the most common life-limiting inherited illness of whites. Most of the
morbidity and mortality in CF stems from impaired mucociliary clearance leading to chronic …

The lack of an appropriate animal model with multiorgan pathology characteristic of the
human form of cystic fibrosis has hampered our understanding of the pathobiology of the …

Cystic fibrosis (CF) is a lethal autosomal recessive disorder characterized by obstructive
pulmonary disease, pancreatic exocrine deficiency, high content of sodium and chloride in …

Chronic obstructive pulmonary disease (COPD) manifests with a variety of clinical
presentations, reflecting its complex pathology. Currently, care focuses on symptom …

Introduction: Obstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive
pulmonary disease (COPD) are causes of high morbidity and mortality worldwide. CF is a …

Pulmonary infection with an exaggerated inflammatory response is the major cause of
morbidity and mortality in cystic fibrosis (CF). The objective of this study was to determine …

Defective epithelial ion transport is the hallmark of the life-limiting genetic disease cystic
fibrosis (CF). This abnormality is caused by mutations in the cystic fibrosis transmembrane …

Although better insights into the natural course of cystic fibrosis (CF) have led to treatment
approaches that have improved pulmonary health and increased the life expectancy of …