RNA interference (RNAi) is emerging as a powerful approach in cancer treatment. siRNA is
an important RNAi tool that can be designed to specifically silence the expression of genes …

Aberrant gene expression can trigger several vital molecular events that not only result in
carcinogenesis but also cause chemoresistance, metastasis and relapse. Gene-based …

Traditional chemotherapeutic agents have long been associated with serious drawbacks
due to the heterogeneity and complexity of human cancer. One of the major hurdles …

Nanotechnology-based combination anticancer therapy offers novel approaches to
overcome the limitations of single-agent administration. The emerging siRNA technology …

Because of the complexity of cancer, combination therapy is becoming increasingly
important to overcome multidrug resistance in cancer and to enhance apoptosis. Cancer …

RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …

Finding out predisposition and makeup alterations in cancer cells has prompted the
exploration of exogenous small interference RNA (siRNA) as a therapeutic agent to deal …

Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

Since the discovery of the Nobel prize-winning mechanism of RNA interference (RNAi) ten
years ago, it has become a promising drug target for the treatment of multiple diseases …