The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is
characterized by the accumulation of insoluble aggregates of Aβ-peptides that are …

Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Synapses have been known for many years to be the crucial target of pathology in different
forms of dementia, in particular Alzheimer's disease (AD). Synapses and their appropriate …

The synapse is the locus of plasticity where short-term alterations in synaptic strength are
converted to long-lasting memories. In addition to the presynaptic terminal and the …

β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer's
disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the …

Synapses may represent a key nidus for dementia including Alzheimer's disease (AD)
pathogenesis. Here we review published studies and present new ideas related to the …

Although β-amyloid (Aβ) plaques and tau neurofibrillary tangles are hallmarks of Alzheimer's
disease (AD) neuropathology, loss of synapses is considered the best correlate of cognitive …

The synaptic connections that form between neurons during development remain plastic
and able to adapt throughout the lifespan, enabling learning and memory. However, during …