Because of its comparatively recent evolution, Homo sapiens exhibit relatively little within-
species genomic diversity. However, because of genome size, a proportionately small …

Chronic heart failure (CHF) is a common disease with high associated morbidity and
mortality, and the outcome appears to be worse in black compared with white patients …

The prevalence of heart failure in the United States remains significantly higher amongst
adult African Americans compared with the prevalence in whites. 1 Additionally, there is a …

Heart failure is a common disease with high levels of morbidity and mortality. A large body of
evidence guiding treatment shows prognostic benefit with beta‐blockers and angiotensin …

Neurohormonal activation is an important driver of heart-failure progression and all
pharmacologic interventions that improve heart-failure survival inhibit this systemic response …

Genetic variants contribute to several steps during heart failure pathophysiology. The
mechanisms include frequent polymorphisms that increase the susceptibility to heart failure …

Modern clinical trials will increasingly have a pharmacogenetic component to allow more
efficient targeting of therapeutics. Investigators are beginning to delineate the genomic basis …

To the Editor: As Wood (May 3 issue) 1 points out, individual and racial differences in the
responses to drugs are increasingly often shown to reflect, at least in part, varying …

Common genetic variants in candidate genes are likely to play a role in susceptibility, and
phenotypic evolution of heart failure (HF), and in the response to a complex influence of …

Heart failure is a common condition responsible for at least 290000 deaths each year in the
United States alone. 1 A small minority of heart failure cases are attributed to Mendelian or …