METHODS Cytokine genotyping was performed utilizing polymerase chain reaction. The
specific gene polymorphisms that were probed for included:− 1082 (G/A),− 819 (T/C), and …

THE mechanisms responsible for development of inflammatory bowel disease (IBD) have
not been fully elucidated, although the main cause of disease pathology is attributed to up …

OBJECTIVES An altered production of cytokines underlies inflammatory bowel disease
(IBD) susceptibility. Various polymorphisms at the IL-10 and TNFα gene promoters control …

Anti‐inflammatory cytokines have an important role in disease, tumour and transplant
processes. Alterations in the regulation of several cytokines have been implicated in a …

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that
genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The …

Background: Changes in cytokine expression have been frequently found in patients with
inflammatory bowel disease (IBD). Cytokine values outside the normal range may be …

Abstract Objective Inflammatory bowel diseases (IBDs), namely ulcerative colitis (UC) and
Crohn's disease (CD), are characterized by chronic and idiopathic inflammatory conditions …

Objective. Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory
diseases of the bowel, the causes of which are not fully known. Ethnic differences in disease …

Objective Inflammatory bowel diseases (IBD) are multifactorial disorders, characterized by
failure to limit the inflammatory response to luminal antigens. Genetic factors play an …

The influence of biallelic polymorphisms in the tumour necrosis factor-alpha (TNFα),
lymphotoxin-alpha (LTα) and interleukin-10 (IL-10) genes on stimulated TNFα and IL-10 …