To analyze the value of real time RT-PCR for monitoring of bcr-abl expression in CML
patients after allogeneic or autologous stem cell transplantation (SCT), we generated pairs …

We identified 103 consecutive patients who, 5 years after allogeneic transplantation for
chronic myeloid leukaemia (CML), were in molecular remission (MR). The 103 patients were …

The degree of tumor load reduction after therapy, which is determined by the degrees of
cytoreduction and cytogenetic response, is an important prognostic factor for patients with …

Although serial detection of bcr-abl positive cells by PCR appears able to identify distinct
patient groups with different risks of relapse following BMT, there remain many unanswered …

Methods of minimal residual disease (MRD) detection in chronic myelogenous leukemia
(CML) include chromosome analysis, reverse transcriptase polymerase chain reaction (RT …

Quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR) assessing the
amount of transcripts of the BCR/ABL gene, the molecular marker of chronic myeloid …

Kinetics of BCR-ABL transcript elimination and its prognostic implications on relapse were
analyzed in patients with chronic myeloid leukemia (CML) after reduced intensity …

We describe the methodology and application of the polymerase chain reaction to detect
BCR-ABL mRNA as a marker for CML cells. The technique is highly sensitive enabling the …

Relapse after allogeneic bone marrow transplantation (BMT) for chronic myelogenous
leukaemia (CML) is thought to result from residual leukaemia cells which survive the …

In chronic myeloid leukemia (CML) the polymerase chain reaction (PCR) can be used to
detect minimal residual disease after bone marrow transplantation (BMT). Previous studies …