The mitogen-activated protein kinase (MAPK) pathway is essential for cellular proliferation,
growth, and survival. Constitutive activation of this pathway by BRAF mutations can cause …

Mitogen-activated protein kinase (MAPK) activation is a common property of human cancers
and is often due to activating mutations in the BRAF and RAS genes. BRAF kinase domain …

Abstract Mitogen Activated Protein Kinase (MAPK) pathway activation is a frequent event in
human cancer and is often the result of activating mutations in the BRAF and RAS …

BRAF is a member of the RAF kinase family, which acts in the ERK/MAP kinase pathway, a
signalling cascade that regulates cellular proliferation, differentiation and survival. Single …

Tumors with mutations in the gene encoding the serine-threonine protein kinase BRAF are
dependent on the MAPK signaling pathway for their growth, what offers an opportunity to test …

BRAF kinase plays an important role in mitogen‐activated protein kinase (MAPK) signaling
and harbors activating mutations in about half of melanomas and in a smaller percentage in …

Abstract The “RAS/BRAF/MEK/ERK” pathway has been associated with human cancers due
to the frequent oncogenic mutations identified in its members. In particular, BRAF is mutated …

BRAF is mutated at a high frequency in various malignancies, including melanoma, papillary
thyroid carcinoma and colorectal adenocarcinoma. BRAF is an element of the …

BRAF is one of the most frequently mutated oncogenes, with an overall frequency of about
50%. Targeting BRAF and its effector mitogen-activated protein kinase kinase 1/2 (MEK1/2) …

Highlights•BRAF alterations lead to unbridled activation of the MAPK pathway which can
result in cancer development and progression.•BRAF and MEK inhibitors led to paradigm …