Human skin diseases are various and induce chronic inflammatory disorders, including
psoriasis, atopic dermatitis and certain forms of ichthyosis. Psoriasis is a chronic …

Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase (Imai et al., 2000), acts as a metabolic
sensor that functions on both histone and non-histone proteins (Leibiger and Berggren …

SIRT1 is a member of a highly conserved gene family (sirtuins) encoding nicotinamide
adenine dinucleotide (NAD)+‐dependent deacetylases, originally found to deacetylate …

Psoriasis, a multisystem chronic disease characterized by abnormal keratinocyte
proliferation, has an unclear pathogenesis where systemic inflammation and oxidative stress …

The natural polyphenolic compound resveratrol (3, 4, 5-trihydroxy-trans-stilbene) has broad
spectrum health beneficial activities including antioxidant, anti-inflammatory, anti-aging, anti …

Abstract Sirtuin 6 (SIRT6) has a critical role in cutaneous Squamous Cell Carcinoma
(cSCC): SIRT6 silencing in skin SCC cells has pro-differentiating effects and SIRT6 deletion …

The protein deacetylase SIRT 1 has been recognized to exert its protective effect by directly
deacetylasing histone and many other transcriptional factors including p53. However, the …

Areca chewing is an important environmental risk factor for development of oral
premalignant lesions and cancer. Epidemiological evidence indicates that areca chewing is …

Baohua Liu and Zhongjun Zhou www. impactaging. com AGING, February 2013, Vol. 5 No 2
www. impactaging. com 94 AGING, February 2013, Vol. 5 No. 2 possible explanation is that …

Psoriasis is a chronic immune-mediated hyperproliferative inflammatory skin disease of
unknown etiology characterized by the appearance of sore patches of thick, red skin with …