Brain tumors cause significant morbidity and mortality even when benign. Completeness of
resection of brain tumors improves quality of life and survival; however, that is often difficult …

Advances in optics and molecular imaging have occurred rapidly in the past decade. One
technique poised to take advantage of these developments is optical spectroscopy (OS). All …

Parkinson's disease (PD) is a chronic, progressive disease involving the globus pallidus
(GP), which is a gray matter mass, surrounded by white matter deep within the brain. During …

The goal of this study is to determine the potential of time-resolved laser-induced
fluorescence spectroscopy (TR-LIFS) as an adjunctive tool for delineation of brain tumor …

Infrared (IR) spectroscopy provides a sensitive molecular fingerprint for tissue without
external markers. Supervised classification models can be trained to identify the tissue type …

Neuropathology frozen section diagnoses are difficult in part because of the small tissue
samples and the paucity of adjunctive rapid intraoperative stains. This study aims to explore …

During glioblastoma surgery, delineation of the brain tumor margins is difficult because the
infiltrated and normal tissues have the same visual appearance. We use a fiber-optical …

A key challenge of central nervous system tumor surgery is to discriminate between brain
regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of …

The optical properties of human brain tumor tissues, including glioblastoma, meningioma,
oligodendroglioma, and metastasis, that were classified into “strong,”“vague,” and …

Glial tumors grow diffusely in the brain. Survival is correlated to the extent of tumor removal,
but tumor borders are often invisible. Resection beyond the borders as defined by …