The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses

K Sawyer, S Mundandhara, AJ Ghio… - Journal of Toxicology …, 2009 - Taylor & Francis
Epidemiologic and occupational studies demonstrated that ambient particulate matter (PM)
and diesel exhaust particles (DEP) exert deleterious effects on human cardiopulmonary …

Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies

S Becker, S Mundandhara, RB Devlin… - Toxicology and applied …, 2005 - Elsevier
In order to better understand how ambient air particulate matter (PM) affect lung health, the
two main airway cell types likely to interact with inhaled particles, alveolar macrophages …

Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles

S Becker, JM Soukup, C Sioutas… - Experimental lung …, 2003 - Taylor & Francis
In the lower airways, macrophages are important regulators of inflammation and
indispensable in their antimicrobial activities. Thus, air pollution particles, which modulate …

Acute effects of PM10 pollution on pulmonary function of smokers with mild to moderate chronic obstructive pulmonary disease

CA Pope, RE Kanner - Am Rev Respir Dis, 1993 - atsjournals.org
This study assessed the association between respirable particulate air pollution (PM10) and
changes in the pulmonary function (FE~, FE~/FVC, and FVC) of smokers with mild to …

Inhalation of PM2. 5 does not modulate host defense or immune parameters in blood or lung of normal human subjects.

SD Harder, JM Soukup, AJ Ghio… - Environmental health …, 2001 - ehp.niehs.nih.gov
We tested the hypothesis that exposure of healthy volunteers to concentrated ambient air
particles (CAPS) between 0.1 and 2.5 microm in diameter is associated with modulation of …

Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles

AP Pietropaoli, MW Frampton, RW Hyde… - Inhalation …, 2004 - Taylor & Francis
Particulate air pollution is associated with asthma exacerbations and increased morbidity
and mortality from respiratory causes. Ultrafine particles (particles less than 0.1 μ m in …

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure

PG Barlow, DM Brown, K Donaldson… - Cell biology and …, 2008 - Springer
Increased levels of particulate air pollution (PM 10) have been implicated as a causal agent
in pulmonary disease exacerbation and increased deaths from respiratory and …

Effects of PM2.5 on Chronic Airway Diseases: A Review of Research Progress

X Li, X Liu - Atmosphere, 2021 - mdpi.com
The adverse effects of polluted air on human health have been increasingly appreciated
worldwide. It is estimated that outdoor air pollution is associated with the death of 4.2 million …

Pulmonary inflammation induced by low-dose particulate matter exposure in mice

YL Chan, B Wang, H Chen, KF Ho… - … of Physiology-Lung …, 2019 - journals.physiology.org
Air pollution is a ubiquitous problem and comprises gaseous and particulate matter (PM).
Epidemiological studies have clearly shown that exposure to PM is associated with impaired …

[引用][C] The mechanism of lung injury caused by PM10

RE Hester, RM Harrison, K Donaldson, W MacNee - 1998 - books.rsc.org
This article addresses the mechanisms of the adverse health effects of PM ie the mass of
particulate air pollution collected by a convention that has 50% efficiency for particles with …