Human neural stem cells genetically modified for brain repair in neurological disorders

SU Kim - Neuropathology, 2004 - Wiley Online Library
Existence of multipotent neural stem cells (NSC) has been known in developing or adult
mammalian CNS, including humans. NSC have the capacity to grow indefinitely and have …

Genetically engineered human neural stem cells for brain repair in neurological diseases

SU Kim - Brain and development, 2007 - Elsevier
Neural stem cells (NSCs) of the central nervous system (CNS) have recently received a
great deal of attention and interest for their therapeutic potential for neurological disorders …

Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model

HJ Lee, KS Kim, EJ Kim, HB Choi, KH Lee, IH Park… - Stem …, 2007 - academic.oup.com
We have generated stable, immortalized cell lines of human NSCs from primary human fetal
telencephalon cultures via a retroviral vector encoding v-myc. HB1. F3, one of the human …

Production and characterization of immortal human neural stem cell line with multipotent differentiation property

SU Kim, A Nagai, E Nakagawa, HB Choi… - Neural Stem Cells …, 2008 - Springer
We document the protocols and methods for the production of immortalized cell lines of
human neural stem cells from the human fetal central nervous system (CNS) cells by using a …

Neural stem cells–a versatile tool for cell replacement and gene therapy in the central nervous system: Section Editor: Roderick R McInnes e‐mail: mcinnes@ sickkids …

V Ourednik, J Ourednik, KI Park, EY Snyder - Clinical genetics, 1999 - Wiley Online Library
In recent years, it has become evident that the developing and even the adult mammalian
central nervous system contains a population of undifferentiated, multipotent cell precursors …

Generation of human cortical neurons from a new immortal fetal neural stem cell line

E Cacci, A Villa, M Parmar, M Cavallaro… - Experimental Cell …, 2007 - Elsevier
Isolation and expansion of neural stem cells (NSCs) of human origin are crucial for
successful development of cell therapy approaches in neurodegenerative diseases …

A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes

L De Filippis, G Lamorte, EY Snyder, A Malgaroli… - Stem …, 2007 - academic.oup.com
The discovery and study of neural stem cells have revolutionized our understanding of the
neurogenetic process, and their inherent ability to adopt expansive growth behavior in vitro …

Multipotent neural progenitor or stem-like cells may be uniquely suited for therapy for some neurodegenerative conditions.

EY Snyder, JD Macklis - Clinical neuroscience (New York, NY), 1995 - europepmc.org
Multipotent neural progenitors or stem cells (or cells which mimic their behavior) are capable
of differentiating along multiple central nervous system (CNS) cell-type lineages, neuronal …

Establishment and Properties of Neural Stem Cell Clones: Plasticity In Vitro and In Vivo

AL Vescovi, EY Snyder - Brain pathology, 1999 - Wiley Online Library
The study of the basic physiology of the neural precursors generated during brain
development is driven by two inextricably linked goals. First, such knowledge is instrumental …

[HTML][HTML] Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A …

SK Vishwakarma, A Bardia, SK Tiwari… - Journal of Advanced …, 2014 - Elsevier
Since last few years, an impressive amount of data has been generated regarding the basic
in vitro and in vivo biology of neural stem cells (NSCs) and there is much far hope for the …