Gefitinib in the treatment of advanced non-small cell lung cancer with brain metastasis

C Wu, LY Li, MZ Wang, L Zhang, XT Zhang… - Zhonghua Zhong liu …, 2007 - europepmc.org
Objective Brain metastasis is frequently found in patient with advanced non-small cell lung
cancer. Gefitinib is a inhibitor of epidermal growth factor receptor and can be used for the …

Primary result of the efficacy and tolerance of gefitinib in advanced non-small cell lung cancer patients with brain metastasis

W Yan, W Ying, W Bin, W Ziping, X Zhang… - Zhongguo Fei Ai …, 2006 - search.proquest.com
吉非替尼是一种口服的表皮生长因子受体酪氨酸激酶抑制剂 (EGFR-TKI), 是治疗晚期非小细胞
肺癌 (NSCLC) 的有效靶向药物之一. 本研究的目的是探讨吉非替尼治疗 NSCLC …

[HTML][HTML] Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial

GL Ceresoli, F Cappuzzo, V Gregorc, S Bartolini… - Annals of oncology, 2004 - Elsevier
Background: Brain metastases are a common occurrence in patients with non-small-cell
lung cancer (NSCLC). Whole-brain radiotherapy (WBRT) is the standard therapy; more …

Evaluation of gefitinib plus radiotherapy in non-small-cell lung cancer patients with brain metastases

H Fu, XL Zhang, Y Xiao, XJ Liu, C Long… - Zhonghua Yi Xue Za …, 2012 - europepmc.org
Objective To evaluate the efficacies of gefitinib plus radiotherapy in the treatment of brain
metastases in non-small-cell lung carcinoma (NSCLC) patients. Methods A retrospective …

Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity

CH Chiu, CM Tsai, YM Chen, SC Chiang, JL Liou… - Lung cancer, 2005 - Elsevier
Gefitinib is active and well tolerated in patients with advanced non-small cell lung cancer
(NSCLC); however, its role in patients with brain metastases has not been clearly defined …

Gefitinib in patients with brain metastases from non–small-cell lung cancer: review of 15 clinical cases

Y Namba, T Kijima, S Yokota, M Niinaka… - Clinical lung cancer, 2004 - Elsevier
The clinical efficacy of gefitinib, a tyrosine kinase inhibitor of epidermal growth factor
receptor (EGFR), on brain metastases (BMs) from non–small-cell lung cancer (NSCLC) was …

Gefitinib for asymptomatic brain metastasis from advanced non‐small cell lung cancer: Report of a favourable outcome

WY Liu, YT Liu, L Yang, Y Zhang, P Liu… - Thoracic …, 2016 - Wiley Online Library
Brain metastasis (BM) is common in patients with non‐small cell lung cancer (NSCLC).
Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have …

Activity of Gefitinib in Central Nervous System Metastases in Patients with Non–Small-Cell Lung Cancer: Two Case Reports and a Review of the Literature

A Gurpide, JL Perez-Gracia, JM Lopez-Picazo… - Clinical lung cancer, 2005 - Elsevier
Gefitinib is the first inhibitor of the epidermal growth factor receptor that has shown activity in
non–small-cell lung cancer (NSCLC), but its potential value in the treatment of central …

Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain

C Wu, YL Li, ZM Wang, Z Li, TX Zhang, Z Wei - Lung Cancer, 2007 - Elsevier
BACKGROUND: Lung cancer is the leading cause of cancer deaths in most countries. In
patients with metastases, such as the brain, the 1-year survival is 10% and most of these …

Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma

T Iuchi, M Shingyoji, T Sakaida, K Hatano, O Nagano… - Lung cancer, 2013 - Elsevier
Background Brain metastases (BM) are a common in patients with lung cancer. Although
whole-brain radiation therapy (WBRT) is the standard therapy, it may have a risk of decline …