Current trends in neoantigen-based cancer vaccines

SY Ho, CM Chang, HN Liao, WH Chou, CL Guo… - Pharmaceuticals, 2023 - mdpi.com
Cancer immunotherapies are treatments that use drugs or cells to activate patients' own
immune systems against cancer cells. Among them, cancer vaccines have recently been …

[HTML][HTML] Driving neoantigen-based cancer vaccines for personalized immunotherapy into clinic: A burdensome journey to promising land

G Yu, X He, X Li, Y Wu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
As tumor-specific antigens, neoantigens are ideal targets for immunotherapy, and their value
in the clinical application has been noted and appreciated recently. Neoantigen-based …

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

E Blass, PA Ott - Nature reviews Clinical oncology, 2021 - nature.com
Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

Therapeutic vaccines targeting neoantigens to induce T-cell immunity against cancers

SC Pao, MT Chu, SI Hung - Pharmaceutics, 2022 - mdpi.com
Cancer immunotherapy has achieved multiple clinical benefits and has become an
indispensable component of cancer treatment. Targeting tumor-specific antigens, also …

Development of neoantigens: from identification in cancer cells to application in cancer vaccines

N Ebrahimi, M Akbari, M Ghanaatian… - Expert Review of …, 2022 - Taylor & Francis
Introduction The discovery of neoantigens as mutated proteins specifically expressed in
tumor cells but not in normal cells has led to improved cancer vaccines. Targeting …

[HTML][HTML] Neoantigen cancer vaccines: a new star on the horizon

X Li, J You, L Hong, W Liu, P Guo… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune
cells or drugs to activate the patient's own immune system and eliminate cancer cells. One of …

[HTML][HTML] Engineering neoantigen vaccines to improve cancer personalized immunotherapy

Z Liu, J Lv, Q Dang, L Liu, S Weng, L Wang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Immunotherapy treatments harnessing the immune system herald a new era of personalized
medicine, offering considerable benefits for cancer patients. Over the past years, tumor …

Challenges in developing personalized neoantigen cancer vaccines

PD Katsikis, KJ Ishii, C Schliehe - Nature Reviews Immunology, 2024 - nature.com
The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Neoantigen cancer vaccines: generation, optimization, and therapeutic targeting strategies

CR Reynolds, S Tran, M Jain, A Narendran - Vaccines, 2022 - mdpi.com
Alternatives to conventional cancer treatments are highly sought after for high-risk
malignancies that have a poor response to established treatment modalities. With research …

Recent development and clinical application of cancer vaccine: targeting neoantigens

RY Pan, WH Chung, MT Chu, SJ Chen… - Journal of …, 2018 - Wiley Online Library
Recently, increasing data show that immunotherapy could be a powerful weapon against
cancers. Comparing to the traditional surgery, chemotherapy or radiotherapy …