Blood pressure–independent effects in rats with human renin and angiotensinogen genes
E Mervaala, DN Müller, F Schmidt, JK Park… - …, 2000 - Am Heart Assoc
The blood pressure–independent effects of angiotensin II (Ang II) were examined in double
transgenic rats (dTGR) harboring human renin and human angiotensinogen genes, in which …
transgenic rats (dTGR) harboring human renin and human angiotensinogen genes, in which …
The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats
L Kopkan, HJ Kramer, Z Husková… - Journal of …, 2005 - journals.lww.com
Objective We investigated the responses of mean arterial pressure and renal blood flow to
intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations …
intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations …
Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension
EMA Mervaala, DN Müller, JK Park, F Schmidt… - …, 1999 - Am Heart Assoc
Hypertension and kidney damage in the double transgenic rat (dTGR) harboring both
human renin and human angiotensinogen genes are dependent on the human components …
human renin and human angiotensinogen genes are dependent on the human components …
Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats
YM Pinto, H Buikema, WH Van Gilst… - Journal of molecular …, 1997 - Springer
To compare hypertensive end-organ damage in two genetic forms of hypertension we
assessed cardiovascular function in two rat strains of genetic hypertension: transgenic rats …
assessed cardiovascular function in two rat strains of genetic hypertension: transgenic rats …
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
B Pilz, E Shagdarsuren, M Wellner, A Fiebeler… - …, 2005 - Am Heart Assoc
We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …
Differential gene expression of renin and angiotensinogen in the TGR (mREN-2) 27 transgenic rat
MA Lee, M Böhm, S Kim, S Bachmann… - …, 1995 - Am Heart Assoc
Transgenic rats carrying the murine Ren-2 gene represent a monogenetic model of
hypertension characterized by low plasma renin and high extrarenal expression of the …
hypertension characterized by low plasma renin and high extrarenal expression of the …
[HTML][HTML] Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
J Theuer, R Dechend, DN Muller, JK Park… - BMC cardiovascular …, 2002 - Springer
Background We are investigating a double transgenic rat (dTGR) model, in which rats
transgenic for the human angiotensinogen and renin genes are crossed. These rats develop …
transgenic for the human angiotensinogen and renin genes are crossed. These rats develop …
Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin …
E MERVAALA, B DEHMEL, V GROSS… - Journal of the …, 1999 - journals.lww.com
The intrarenal factors responsible for hypertension in double-transgenic rats (dTGR)
harboring human renin and human angiotensinogen genes are unclear. The pressure …
harboring human renin and human angiotensinogen genes are unclear. The pressure …
Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats
KD Mitchell, SM Jacinto… - American Journal of …, 1997 - journals.physiology.org
The present study was performed to assess the plasma and kidney levels of angiotensin I
(ANG I) and ANG II during prehypertensive (4-to 5-wk old), development (6-to 8-wk old), and …
(ANG I) and ANG II during prehypertensive (4-to 5-wk old), development (6-to 8-wk old), and …
High human renin hypertension in transgenic rats
J Bohlender, A Fukamizu, A Lippoldt, T Nomura… - …, 1997 - Am Heart Assoc
We developed a model of spontaneously high human renin hypertension in the rat by
producing two transgenic strains, one for human angiotensinogen with the endogenous …
producing two transgenic strains, one for human angiotensinogen with the endogenous …
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