The blood pressure–independent effects of angiotensin II (Ang II) were examined in double
transgenic rats (dTGR) harboring human renin and human angiotensinogen genes, in which …

Objective We investigated the responses of mean arterial pressure and renal blood flow to
intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations …

Hypertension and kidney damage in the double transgenic rat (dTGR) harboring both
human renin and human angiotensinogen genes are dependent on the human components …

To compare hypertensive end-organ damage in two genetic forms of hypertension we
assessed cardiovascular function in two rat strains of genetic hypertension: transgenic rats …

We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …

Transgenic rats carrying the murine Ren-2 gene represent a monogenetic model of
hypertension characterized by low plasma renin and high extrarenal expression of the …

Background We are investigating a double transgenic rat (dTGR) model, in which rats
transgenic for the human angiotensinogen and renin genes are crossed. These rats develop …

The intrarenal factors responsible for hypertension in double-transgenic rats (dTGR)
harboring human renin and human angiotensinogen genes are unclear. The pressure …

The present study was performed to assess the plasma and kidney levels of angiotensin I
(ANG I) and ANG II during prehypertensive (4-to 5-wk old), development (6-to 8-wk old), and …

We developed a model of spontaneously high human renin hypertension in the rat by
producing two transgenic strains, one for human angiotensinogen with the endogenous …