Mangiferin ameliorates obesity-associated inflammation and autophagy in high-fat-diet-fed mice: In silico and in vivo approaches

JW Noh, HY Lee, BC Lee - International Journal of Molecular Sciences, 2022 - mdpi.com
Obesity-induced insulin resistance is the fundamental cause of metabolic syndrome.
Accordingly, we evaluated the effect of mangiferin (MGF) on obesity and glucose …

Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation in high-fat-diet induced mice

H Wang, YY Zhu, L Wang, T Teng, M Zhou… - Biomedicine & …, 2017 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally. The
progression of NAFLD is complex and associated with inflammation, oxidative stress …

Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities

G Xiang, S Guo, N Xing, Q Du, J Qin, H Gao… - The American Journal …, 2024 - World Scientific
Metabolic syndrome (MetS) represents a considerable clinical and public health burden
worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as …

Dual mode action of mangiferin in mouse liver under high fat diet

J Lim, Z Liu, P Apontes, D Feng, JE Pessin, AA Sauve… - PloS one, 2014 - journals.plos.org
Chronic over-nutrition is a major contributor to the spread of obesity and its related metabolic
disorders. Development of therapeutics has been slow compared to the speedy increase in …

A high-throughput metabolomic approach to explore the regulatory effect of mangiferin on metabolic network disturbances of hyperlipidemia rats

C Zhou, G Li, Y Li, L Gong, Y Huang, Z Shi, S Du… - Molecular …, 2015 - pubs.rsc.org
This paper was designed to study metabolomic characters of the high-fat diet (HFD)-induced
hyperlipidemia and the intervention effects of Mangiferin (MG). In this study, we aimed to …

Mangiferin accelerates glycolysis and enhances mitochondrial bioenergetics

Z Liu, P Apontes, EV Fomenko, N Chi… - International Journal of …, 2018 - mdpi.com
One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by
skeletal muscle, which can be exacerbated by chronic high caloric intake. Previously, we …

Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes …

Y Zhong, Y Xu, Y Tan, X Zhang, R Wang… - … of Pharmaceutical and …, 2023 - Elsevier
Mangiferin, a natural C-glucoside xanthone, is one of the major bioactive ingredients
derived from the dry rhizome of Anemarrhenae rhizome, which has been reported to exhibit …

Mangiferin ameliorates insulin resistance by inhibiting inflammation and regulatiing adipokine expression in adipocytes under hypoxic condition

Y Chao-Qiang, XU Jing-Hua, YAN Dan-Dan… - Chinese journal of …, 2017 - Elsevier
Adipose tissue hypoxia has been recognized as the initiation of insulin resistance
syndromes. The aim of the present study was to investigate the effects of mangiferin on the …

Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes-and metabolic syndrome-induced changes in experimental rats

RK Suman, IR Mohanty, U Maheshwari… - … syndrome and obesity …, 2016 - Taylor & Francis
Background Mangiferin (MNG) is known to possess antidiabetic and antioxidant activity.
However, there is no experimental evidence presently available in the literature with regard …

Medicinal properties of mangiferin, structural features, derivative synthesis, pharmacokinetics and biological activities

O Benard, Y Chi - Mini reviews in medicinal chemistry, 2015 - ingentaconnect.com
The identification of biologically active and potentially therapeutically useful
pharmacophores from natural products has been a long-term focus in the pharmaceutical …