Voltage-gated Na+ channels are essential for the amplitude and upstroke velocity of the
cardiac action potential, which are important determinants for impulse propagation and …

Mutations in SCN5A encoding the principal Na+ channel α-subunit expressed in human
heart (NaV1. 5) have recently been linked to an inherited form of dilated cardiomyopathy …

Variants in the SCN 2A gene, encoding the voltage‐gated sodium channel NaV1. 2, cause a
variety of neuropsychiatric syndromes with different severity ranging from self‐limiting …

The SCN5A gene encodes Na v 1.5, which, as the cardiac voltage-gated Na+ channel's
pore-forming α subunit, is crucial for the initiation and propagation of atrial and ventricular …

Cardiac sodium channel are protein complexes that are expressed in the sarcolemma of
cardiomyocytes to carry a large inward depolarizing current (I Na) during phase 0 of the …

Background: Accurately predicting the impact of rare nonsynonymous variants on disease
risk is an important goal in precision medicine. Variants in the cardiac sodium channel …

The SCN5A gene encodes the alpha-subunit of the Na v 1.5 ion channel protein, which is
responsible for the sodium inward current (I Na). Since 1995 several hundred mutations in …

Background: The SCN5A gene encodes the α subunit of the cardiac voltage-gated sodium
channel, Na V 1.5. The missense mutation, D1275N, has been associated with a range of …

Background: The potential pathophysiological role of common SCN5A polymorphisms in
cardiac arrhythmias has been increasingly recognized. However, little is known about the …

Variations in the gene encoding for the major sodium channel (Nav1. 5) in the heart,
SCN5A, has been shown to cause a number of arrhythmia syndromes (with or without …