The immune system must be able to discriminate between self and non-self. However,
mechanisms of doing so sometimes fail, causing the activation and clonal expansion of …

Autoimmune diseases, which comprise over 80 clinically distinct conditions, are
characterized by the presence of autoantibodies or autoreactive T cells directed against self …

Autoimmune diseases appear to be increasing throughout the world, yet their rarity,
heterogeneity and complex etiologies have limited our understanding of their pathogeneses …

The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …

The past 12 months have witnessed several critical advancements and new particularly
promising lines of evidence on the pathogenesis and clinical management of autoimmune …

The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

Autoimmune diseases are an ever-growing problem for patients as well as for the economy.
It has been estimated that 5–10% of the general population suffer from any kind of …

Several matters concerning the term “Autoimmunity” have arisen the last two decades. Most
researchers agree that a degree of natural autoimmunity in the absence of disease is …

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the
multifactorial origin and diversity of expression of autoimmune diseases in humans. The …

[Frontiers in Bioscience E1, 501-509, June 1, 2009] 501 The mosaic of autoimmunity: the role of
environmental factors Jozelio Page 1 [Frontiers in Bioscience E1, 501-509, June 1, 2009] 501 …