A new hypothesis of sex-differences in temporomandibular disorders: estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium …
RY Bi, Y Ding, YH Gan - Medical hypotheses, 2015 - Elsevier
Objective: Temporomandibular disorders (TMD) are an assorted set of clinical conditions
characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or …
characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or …
Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ
RY Bi, Z Meng, P Zhang, XD Wang, Y Ding, YH Gan - PLoS One, 2017 - journals.plos.org
Background Temporomandibular disorders (TMDs) have the highest prevalence in women
of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not …
of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not …
Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage‐Gated Sodium Channel 1.7 in Trigeminal Ganglion
RY Bi, XY Zhang, P Zhang, Y Ding… - Pain Research and …, 2020 - Wiley Online Library
Background. Women with temporomandibular disorders (TMDs) experience some
amelioration of pain during pregnancy. Progesterone increases dramatically and steadily …
amelioration of pain during pregnancy. Progesterone increases dramatically and steadily …
Involvement of trigeminal ganglionic Nav1.7 in hyperalgesia of inflamed temporomandibular joint is dependent on ERK1/2 phosphorylation of glial cells in rats
RY Bi, XX Kou, Z Meng, XD Wang… - European Journal of …, 2013 - Wiley Online Library
Background Inflammation is a major cause of temporomandibular disorder‐related pain. The
N av1. 7 sodium channel has a critical function in pain perceptions. However, whether and …
N av1. 7 sodium channel has a critical function in pain perceptions. However, whether and …
NMDA receptor blockade reduces temporomandibular joint-evoked activity of trigeminal subnucleus caudalis neurons in an estrogen-dependent manner
A Tashiro, K Okamoto, DA Bereiter - Neuroscience, 2009 - Elsevier
Estrogen status is a risk factor in painful temporomandibular disorders (TMJD). Previously
we reported that estradiol (E2) enhanced nociceptive processing of TMJ input by neurons in …
we reported that estradiol (E2) enhanced nociceptive processing of TMJ input by neurons in …
Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons
NM Flake, DB Bonebreak… - Journal of …, 2005 - journals.physiology.org
Several painful conditions, including temporomandibular disorders (TMD), are more
prevalent and more severe in women than in men. Although the physiological basis for this …
prevalent and more severe in women than in men. Although the physiological basis for this …
The effects of estrogen on temporomandibular joint pain as influenced by trigeminal caudalis neurons
A Tashiro, DA Bereiter - Journal of Oral Science, 2020 - jstage.jst.go.jp
The signs and symptoms of persistent temporomandibular joint (TMJ)/muscle disorder
(TMJD) pain suggest the existence of a central neural dysfunction or a problem of pain …
(TMJD) pain suggest the existence of a central neural dysfunction or a problem of pain …
[PDF][PDF] Non-steroidal anti-inflammatory drugs attenuate hyperalgesia and block upregulation of trigeminal ganglionic sodium channel 1.7 after induction of …
BI Rui Yun, Y Ding, YH Gan - Chin J Dent Res, 2016 - cjdrcsa.com
Objective: To investigate the association between the analgesic effect of non-steroidal
antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1. 7) expression in the …
antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1. 7) expression in the …
Sex differences in estradiol secretion by trigeminal brainstem neurons
DA Bereiter, R Thompson, M Rahman - Frontiers in Integrative …, 2019 - frontiersin.org
Estrogen status is a significant risk factor in the development of temporomandibular joint
disorders (TMD). Classically, estrogen status is thought to derive mainly from ovarian …
disorders (TMD). Classically, estrogen status is thought to derive mainly from ovarian …
Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction
J Puri, LL Bellinger, PR Kramer - Journal of cellular physiology, 2011 - Wiley Online Library
Females report temporomandibular joint (TMJ) pain more than men and studies suggest
estrogen modulates this pain response. Our goal in this study was to determine genes that …
estrogen modulates this pain response. Our goal in this study was to determine genes that …