TB-IRIS after initiation of antiretroviral therapy is associated with expansion of preexistent Th1 responses against Mycobacterium tuberculosis antigens

R Vignesh, N Kumarasamy, A Lim… - JAIDS Journal of …, 2013 - journals.lww.com
Background: The role of T-cell responses against Mycobacterium tuberculosis antigens in
tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is unclear …

Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated …

S Ravimohan, N Tamuhla, K Nfanyana… - Clinical Infectious …, 2016 - academic.oup.com
Background. The immunopathogenesis of paradoxical tuberculosis-associated immune
reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the …

Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction

N Gopalan, BB Andrade… - Expert review of clinical …, 2014 - Taylor & Francis
Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) is an exaggerated,
dysregulated immune response against dead or viable antigens of Mycobacterium …

The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research

NF Walker, C Stek, S Wasserman… - Current Opinion in …, 2018 - journals.lww.com
Specific biomarkers would aid in identifying high-risk patients for interventions and a
diagnostic test is needed. Clinicians should consider prednisone for TB-IRIS prevention in …

Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome

S Marais, G Meintjes, DJ Pepper… - Clinical infectious …, 2013 - academic.oup.com
Background. Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a
common cause of deterioration in human immunodeficiency virus (HIV)–infected patients …

Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance

G Meintjes, MX Rangaka, G Maartens… - Clinical infectious …, 2009 - academic.oup.com
Background. Tuberculosis (TB) immune reconstitution inflammatory syndrome (IRIS) is
emerging as an important early complication of combination antiretroviral therapy in patients …

Immunologic markers as predictors of tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and tuberculosis coinfected persons in Thailand

HV Tieu, J Ananworanich, A Avihingsanon… - AIDS research and …, 2009 - liebertpub.com
This study analyzes immunologic markers to predict and diagnose tuberculosis-associated
immune reconstitution inflammatory syndrome (TB-IRIS) in HIV and TB coinfected adults …

Immune reconstitution inflammatory syndrome of tuberculosis among HIV-infected patients receiving antituberculous and antiretroviral therapy

W Manosuthi, S Kiertiburanakul, T Phoorisri… - Journal of Infection, 2006 - Elsevier
OBJECTIVE: To determine the frequency, risk factors and mortality rate of immune
reconstitution inflammatory syndrome (IRIS) of tuberculosis (TB) in patients co-infected with …

Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome

M Bonnet, E Baudin, IV Jani, E Nunes… - PLoS …, 2013 - journals.plos.org
Objectives and Design We used data from a randomized trial of HIV-tuberculosis co-infected
patients in Mozambique to determine the incidence and predictors of paradoxical …

[HTML][HTML] TB-IRIS pathogenesis and new strategies for intervention: Insights from related inflammatory disorders

PM Cevaal, LG Bekker, S Hermans - Tuberculosis, 2019 - Elsevier
In almost one in five HIV/tuberculosis (TB) co-infected patients, initiation of antiretroviral
therapy (ART) is complicated by TB immune reconstitution inflammatory syndrome (TB-IRIS) …