Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …

Objective. Sarcoidosis is a systemic inflammatory disorder characterized by granulomas.
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 …

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …

Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than
immunological criteria. We aimed to characterise patterns of CD4+ T-cell lineage plasticity …

Sarcoidosis is a systemic granulomatous disease, which is thought to result from an aberrant
immune response. CD4+ T lymphocytes play an important role in the development of …

The lung-draining mediastinal lymph nodes (MLNs) are currently widely used to diagnose
sarcoidosis. We previously reported that T-helper (Th) 17.1 cells are responsible for the …

Sarcoidosis is a systemic inflammatory disorder of unknown etiology characterized by tissue
infiltration with macrophages and lymphocytes and associated non-caseating granuloma …

Background: Sarcoidosis is a systemic granulomatous disorder of unknown origin.
Lymphocytic inflammation is dominated by expression of Th1 type cytokines such as tumour …

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive disorder
characterized by an inflammatory response to cigarette smoke. A disorder in immune …

Introduction: The pathogenesis of sarcoidosis is not yet completely understood, although in
recent years our knowledge has made considerable progress. Areas covered: This review …