The transcriptional programs that regulate blood vessel formation are largely unknown. In
this paper, we examine the role of the zinc finger transcription factor LKLF in murine blood …

Background Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during
embryonic development. In adult mice, KLF2 regulates expression of the tight junction …

Vasculogenesis, angiogenesis, and maturation are three major phases of the development
of blood vessels. Although many receptors required for blood vessel formation have been …

The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger
transcription factors given their important biological roles which include the vasculature …

Blood and endothelium arise in close association during development, possibly from a
common precursor, the hemangioblast [1–4]. Genes essential for blood and endothelial …

The protein product of the Delta‐like 1 (Dlk1) gene belongs to the Delta‐Notch family of
signaling molecules, proteins involved in cell fate determination in many tissues during …

The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood
flow into molecular signals responsible for a wide range of biological responses. Following …

Expression of the hyaluronan receptor LYVE‐1 is one of few available criteria used to
discriminate lymphatic vessels from blood vessels. Until now, endothelial LYVE‐1 …

Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription
factors and is highly expressed in lung with limited distribution in other tissues. Mice lacking …

Endothelial cells (EC) translate biomechanical forces into functional and phenotypic
responses that play important roles in cardiac development. Specifically, EC in areas of high …