Direct prediction of antimicrobial resistance in Pseudomonas aeruginosa by metagenomic next-generation sequencing

L Cao, H Yang, Z Huang, C Lu, F Chen… - Frontiers in …, 2024 - frontiersin.org
Objective Pseudomonas aeruginosa has strong drug resistance and can tolerate a variety of
antibiotics, which is a major problem in the management of antibiotic-resistant infections …

Direct prediction of carbapenem resistance in Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing

B Liu, J Gao, XF Liu, G Rao, J Luo, P Han… - Journal of Clinical …, 2023 - Am Soc Microbiol
Carbapenem resistance is a major concern in the management of antibiotic-resistant
Pseudomonas aeruginosa infections. The direct prediction of carbapenem-resistant …

Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes

J Jeukens, I Kukavica-Ibrulj… - FEMS microbiology …, 2017 - academic.oup.com
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The
accessibility of microbial whole-genome sequencing offers an invaluable opportunity for …

Enhancing predictions of antimicrobial resistance of pathogens by expanding the potential resistance gene repertoire using a pan-genome-based feature selection …

MR Yang, YW Wu - BMC bioinformatics, 2022 - Springer
Background Predicting which pathogens might exhibit antimicrobial resistance (AMR) based
on genomics data is one of the promising ways to swiftly and precisely identify AMR …

Genome-wide mutation scoring for machine-learning-based antimicrobial resistance prediction

P Májek, L Lüftinger, S Beisken, T Rattei… - International Journal of …, 2021 - mdpi.com
The prediction of antimicrobial resistance (AMR) based on genomic information can improve
patient outcomes. Genetic mechanisms have been shown to explain AMR with accuracies in …

Detection of Antibiotic Resistance Genes in Pseudomonas aeruginosa by Whole Genome Sequencing

OB Ahmed - Infection and Drug Resistance, 2022 - Taylor & Francis
Background Multidrug-resistant Pseudomonas aeruginosa has become a hazard to public
health, making medical treatment challenging and ineffective. Whole-genome sequencing …

Rapid AMR prediction in Pseudomonas aeruginosa combining MALDI–TOF MS with DNN model

J Fu, F He, J Xiao, Z Liao, L He, J He… - Journal of Applied …, 2023 - academic.oup.com
Background Pseudomonas aeruginosa is a significant clinical pathogen that poses a
substantial threat due to its extensive drug resistance. The rapid and precise identification of …

Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning‐enabled molecular diagnostics

A Khaledi, A Weimann, M Schniederjans… - EMBO molecular …, 2020 - embopress.org
Limited therapy options due to antibiotic resistance underscore the need for optimization of
current diagnostics. In some bacterial species, antimicrobial resistance can be …

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa

A Khaledi, M Schniederjans, S Pohl… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Emerging resistance to antimicrobials and the lack of new antibiotic drug candidates
underscore the need for optimization of current diagnostics and therapies to diminish the …

Core genome multilocus sequence typing and antibiotic susceptibility prediction from whole-genome sequence data of multidrug-resistant Pseudomonas aeruginosa …

SA Cunningham, AR Eberly, S Beisken… - Microbiology …, 2022 - Am Soc Microbiol
Over the past decade, whole-genome sequencing (WGS) has overtaken traditional bacterial
typing methods for studies of genetic relatedness. Further, WGS data generated during …