Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma
S Giunti, A Antonelli, A Amorosi… - International journal of …, 2013 - Wiley Online Library
Parafollicular C‐cell‐derived medullary thyroid cancer (MTC) comprises 3% to 4% of all
thyroid cancers. While cytotoxic treatments have been shown to have limited efficacy …
thyroid cancers. While cytotoxic treatments have been shown to have limited efficacy …
Personalized medicine in medullary thyroid carcinoma: A broad review of emerging treatments
Medullary thyroid carcinoma (MTC) arises from parafollicular cells in the thyroid gland, and
although rare, it represents an aggressive type of thyroid cancer. MTC is recognized for its …
although rare, it represents an aggressive type of thyroid cancer. MTC is recognized for its …
Preclinical evaluation of novel tyrosine-kinase inhibitors in medullary thyroid cancer
D Saronni, G Gaudenzi, A Dicitore, S Carra… - Cancers, 2022 - mdpi.com
Simple Summary Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor arising from
parafollicular calcitonin-secreting C cells of the thyroid. Most of the patients affected by MTC …
parafollicular calcitonin-secreting C cells of the thyroid. Most of the patients affected by MTC …
Treating medullary thyroid cancer in the age of targeted therapy
ME Cabanillas, MI Hu, C Jimenez… - … journal of endocrine …, 2014 - Taylor & Francis
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor deriving from the thyroid
parafollicular cell. Thyroidectomy continues to serve as the primary initial treatment for this …
parafollicular cell. Thyroidectomy continues to serve as the primary initial treatment for this …
New drugs for medullary thyroid cancer: new promises?
C Spitzweg, JC Morris, KC Bible - Endocrine-Related Cancer, 2016 - erc.bioscientifica.com
Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing
parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a …
parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a …
Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma
MQ Almeida, AO Hoff - Current opinion in oncology, 2012 - journals.lww.com
Summary Recently, vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor
receptor (VEGFR) 2 and VEGFR 3, RET, and epidermal growth factor receptor (EGFR), was …
receptor (VEGFR) 2 and VEGFR 3, RET, and epidermal growth factor receptor (EGFR), was …
MANAGEMENT OF ENDOCRINE DISEASE: Medullary thyroid cancer: from molecular biology and therapeutic pitfalls to future targeted treatment perspectives
K Saltiki, G Simeakis, O Karapanou… - European Journal of …, 2022 - academic.oup.com
During the last decades, knowledge of the molecular biology in medullary thyroid carcinoma
(MTC) and specifically on the role of rearranged during transfection (RET)-activating …
(MTC) and specifically on the role of rearranged during transfection (RET)-activating …
Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
I Rapa, E Saggiorato, D Giachino… - The Journal of …, 2011 - academic.oup.com
Context: The genetic pathways involved in medullary thyroid carcinomas (MTC), except for
RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a …
RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a …
[HTML][HTML] Recent advances in the biology and therapy of medullary thyroid carcinoma
B Nelkin - F1000Research, 2017 - ncbi.nlm.nih.gov
Medullary thyroid cancer (MTC) is a relatively uncommon yet prognostically significant
thyroid cancer. Several recent advances in the biology and current or potential treatment of …
thyroid cancer. Several recent advances in the biology and current or potential treatment of …
Medullary thyroid cancer: clinical characteristics and new insights into therapeutic strategies targeting tyrosine kinases
S Rajabi, M Hedayati - Molecular Diagnosis & Therapy, 2017 - Springer
Medullary thyroid carcinoma (MTC) is a hyperplasia of thyroid C-cells, accounting for 5–10%
of all thyroid cancers. MTCs may appear as sporadic or hereditary forms, and several …
of all thyroid cancers. MTCs may appear as sporadic or hereditary forms, and several …
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