Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma

S Giunti, A Antonelli, A Amorosi… - International journal of …, 2013 - Wiley Online Library
Parafollicular C‐cell‐derived medullary thyroid cancer (MTC) comprises 3% to 4% of all
thyroid cancers. While cytotoxic treatments have been shown to have limited efficacy …

Personalized medicine in medullary thyroid carcinoma: A broad review of emerging treatments

RS Martins, TT Jesus, L Cardoso, P Soares… - Journal of Personalized …, 2023 - mdpi.com
Medullary thyroid carcinoma (MTC) arises from parafollicular cells in the thyroid gland, and
although rare, it represents an aggressive type of thyroid cancer. MTC is recognized for its …

Preclinical evaluation of novel tyrosine-kinase inhibitors in medullary thyroid cancer

D Saronni, G Gaudenzi, A Dicitore, S Carra… - Cancers, 2022 - mdpi.com
Simple Summary Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor arising from
parafollicular calcitonin-secreting C cells of the thyroid. Most of the patients affected by MTC …

Treating medullary thyroid cancer in the age of targeted therapy

ME Cabanillas, MI Hu, C Jimenez… - … journal of endocrine …, 2014 - Taylor & Francis
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor deriving from the thyroid
parafollicular cell. Thyroidectomy continues to serve as the primary initial treatment for this …

New drugs for medullary thyroid cancer: new promises?

C Spitzweg, JC Morris, KC Bible - Endocrine-Related Cancer, 2016 - erc.bioscientifica.com
Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing
parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a …

Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma

MQ Almeida, AO Hoff - Current opinion in oncology, 2012 - journals.lww.com
Summary Recently, vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor
receptor (VEGFR) 2 and VEGFR 3, RET, and epidermal growth factor receptor (EGFR), was …

MANAGEMENT OF ENDOCRINE DISEASE: Medullary thyroid cancer: from molecular biology and therapeutic pitfalls to future targeted treatment perspectives

K Saltiki, G Simeakis, O Karapanou… - European Journal of …, 2022 - academic.oup.com
During the last decades, knowledge of the molecular biology in medullary thyroid carcinoma
(MTC) and specifically on the role of rearranged during transfection (RET)-activating …

Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma

I Rapa, E Saggiorato, D Giachino… - The Journal of …, 2011 - academic.oup.com
Context: The genetic pathways involved in medullary thyroid carcinomas (MTC), except for
RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a …

[HTML][HTML] Recent advances in the biology and therapy of medullary thyroid carcinoma

B Nelkin - F1000Research, 2017 - ncbi.nlm.nih.gov
Medullary thyroid cancer (MTC) is a relatively uncommon yet prognostically significant
thyroid cancer. Several recent advances in the biology and current or potential treatment of …

Medullary thyroid cancer: clinical characteristics and new insights into therapeutic strategies targeting tyrosine kinases

S Rajabi, M Hedayati - Molecular Diagnosis & Therapy, 2017 - Springer
Medullary thyroid carcinoma (MTC) is a hyperplasia of thyroid C-cells, accounting for 5–10%
of all thyroid cancers. MTCs may appear as sporadic or hereditary forms, and several …