Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate
through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates …

Circulating platelets exhibit rapid signaling and adhesive responses to collagen that
facilitate hemostasis at sites of vessel injury. Because platelets are anuclear, their collagen …

The elimination of apoptotic cells, called efferocytosis, is fundamentally important for tissue
homeostasis and prevents the onset of inflammation and autoimmunity. Serum proteins are …

The leukocyte integrin α M β 2/Mac-1 appears to support the inflammatory response through
multiple ligands, but local engagement of fibrin (ogen) may be particularly important for …

Induction of β1 integrin (CD49/CD29) expression in polymorphonuclear leukocytes (PMN)
has been shown to be associated with transendothelial migration recently. Yet, β1 integrin …

We have recently demonstrated that promatrix metalloproteinases (proMMPs), particularly
proMMP-9, are potent ligands of the leukocyte β 2 integrins. We studied here the complex …

Although the roles of plasminogen and plasmin in mediating blood clot dissolution are well
known, the availability of mice deficient for components of the fibrinolytic system has allowed …

There are two plasminogen activators (PAs), urokinase type-PA (u-PA) and tissue type-PA (t-
PA). While u-PA is considered to be involved in cellular migration and tissue remodeling and …

Plasminogen plays an integral role in the inflammatory response, and this participation is
likely to depend on its interaction with cell surfaces. It has previously been reported that …

In addition to its preeminent role in fibrinolysis, the plasminogen system is believed to play a
key role in mediating cell migration. Leukocyte migration into the vessel wall is a key and …