OBJECTIVE: Leukocyte recruitment to inflammatory sites is a prominent feature of acute and
chronic inflammation. Instrumental in this process is the coordinated upregulation of …

Plasminogen knock-out (PG−/−) mice provide an unique opportunity for the study of
alternative mediators of fibrinolysis. Polymorphonuclear leucocytes (PMNs) contain non …

During cell migration, integrin attachments to the substratum provide the means to generate
the traction and force necessary to achieve locomotion. Once the cell has moved over these …

The fibrinolytic system provides an essential means to remove fibrin deposits and blood
clots. The actual protease responsible for this is plasmin, formed from its precursor …

Hematopoietic stem cells (HSCs) can differentiate and proliferate in response to
hematopoietic stress (eg, myelosuppression, infections, and allergic reactions), thereby …

The interaction of plasminogen with platelets and their localization during thrombus
formation and fibrinolysis under flow are not defined. Using a novel model of whole blood …

Polymorphonuclear neutrophils (PMNs) and macrophages are crucial contributors to
neovascularization, serving as a source of chemokines, growth factors, and proteases. α M β …

Background Interaction of fibrinogen with specific leukocyte integrins of monocytes may link
coagulation and inflammation, however, the precise mechanism of fibrinogen leading to the …

Accumulation of leukocytes in inflamed tissue involves their migration through vascular
endothelium and then in the connective tissue. Recently we utilized a barrier of human …

α M β 2 integrin receptors on myeloid cells mediate the adhesion or uptake of diverse
ligands. Ligand binding occurs in the α M chain, which is composed of an I domain and a …