Activation of telomerase is a critical step in the development of about 85% of human
cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are …

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

In this review, we summarise the function and structure of telomerase reverse transcriptase
(TERT) in humans, including its regulation. The dysregulation of telomerase through TERT …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

The reactivation of telomerase reverse transcriptase (TERT) protein is the principal
mechanism of telomere maintenance in cancer cells. Mutations in the TERT promoter …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Background Several somatic mutation hotspots were recently identified in the telomerase
reverse transcriptase (TERT) promoter region in human cancers. Large scale studies of …