Telomerase expression and telomere maintenance are critical for long-term cell proliferation
and survival, and they play important roles in development, aging, and cancer. Cumulating …

Most human cancer cells are thought to acquire the ability to divide beyond the capacity of
normal somatic cells through illegitimately activating the gene hTERT, which encodes the …

Activation of telomerase is a crucial step during cellular immortalization and malignant
transformation of human cells and requires the induction of the catalytic component, human …

The enzyme telomerase plays a crucial role in cellular proliferation and tumorigenesis. By
adding hexameric repeats to chromosome ends, it prevents telomeric loss and, thus, entry …

Activation of telomerase is one of the rate-limiting steps in human cell immortalization and
carcinogenesis. Human telomerase is composed of at least two protein subunits and an …

Direct genetic manipulations have shown that telomerase‐mediated telomere elongation
plays a key role in determining cellular replicative capacity and senescence. The …

The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme
complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of …

Recent interest in the regulation of telomerase, the enzyme that maintains chromosomal
termini, has lead to the discovery and characterization of the catalytic subunit of telomerase …

TERT promoter mutations (TPMs) are the most common noncoding mutations in cancer. The
timing and consequences of TPMs have not been fully established. Here, we show that …

Telomerase is expressed in early human development and then becomes silenced in most
normal tissues. Because~ 90% of primary human tumors express telomerase and generally …