Epigenetic modifications such as histone modification play an important role in
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …

Histone deacetylases (HDACs) are enzymes that can control transcription by modifying
chromatin conformation, molecular interactions between the DNA and the proteins as well …

The acetylation state of histone is reversibly regulated by histone acetyltransferase (HAT)
and deacetylase (HDAC). An imbalance of this reaction leads to an aberrant behavior of the …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Histone deacetylases (HDACs) and histone acetyltransferases are enzymes that regulate
chromatin structure and function through the removal and addition, respectively, of the acetyl …

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical
role in the regulation of gene expression. Histone acetylation induced by histone acetyl …

Posttranslational modifications of core histones are central to the regulation of gene
expression. Histone deacetylases (HDACs) repress transcription by deacetylating histones …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each
other to regulate gene expression by altering chromatin structure. Aberrant HDAC activity …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …

It has been shown that epigenetic modifications play an important role in tumorigenesis.
Thus, affecting epigenetic tumorigenic alterations can represent a promising strategy for …