Analysis of competing HIV-1 splice donor sites uncovers a tight cluster of splicing regulatory elements within exon 2/2b
AL Brillen, L Walotka, F Hillebrand, L Müller… - Journal of …, 2017 - Am Soc Microbiol
The HIV-1 accessory protein Vif is essential for viral replication by counteracting the host
restriction factor APOBEC3G (A3G), and balanced levels of both proteins are required for …
restriction factor APOBEC3G (A3G), and balanced levels of both proteins are required for …
Regulation of vif mRNA Splicing by Human Immunodeficiency Virus Type 1 Requires 5′ Splice Site D2 and an Exonic Splicing Enhancer To Counteract Cellular …
D Mandal, CM Exline, Z Feng, CM Stoltzfus - Journal of virology, 2009 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif is encoded by an
incompletely spliced mRNA resulting from splicing of the major splice donor in the HIV-1 …
incompletely spliced mRNA resulting from splicing of the major splice donor in the HIV-1 …
A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction
M Widera, F Hillebrand, S Erkelenz, AAJ Vasudevan… - Retrovirology, 2014 - Springer
Background The HIV-1 accessory proteins, Viral Infectivity Factor (Vif) and the pleiotropic
Viral Protein R (Vpr) are important for efficient virus replication. While in non-permissive cells …
Viral Protein R (Vpr) are important for efficient virus replication. While in non-permissive cells …
An Intronic G Run within HIV-1 Intron 2 Is Critical for Splicing Regulation of vif mRNA
M Widera, S Erkelenz, F Hillebrand, A Krikoni… - Journal of …, 2013 - Am Soc Microbiol
Within target T lymphocytes, human immunodeficiency virus type I (HIV-1) encounters the
retroviral restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic …
retroviral restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic …
Natural single-nucleotide variations in the HIV-1 genomic SA1prox region can alter viral replication ability by regulating Vif expression levels
M Nomaguchi, N Doi, Y Sakai, H Ode, Y Iwatani… - Journal of …, 2016 - Am Soc Microbiol
We previously found that natural single-nucleotide variations located within a proximal
region of splicing acceptor 1 (SA1prox) in the HIV-1 genome could alter the viral replication …
region of splicing acceptor 1 (SA1prox) in the HIV-1 genome could alter the viral replication …
Genome-wide analysis of heterogeneous nuclear ribonucleoprotein (hnRNP) binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing
SB Kutluay, A Emery, SR Penumutchu… - Journal of …, 2019 - Am Soc Microbiol
Alternative splicing of HIV-1 mRNAs increases viral coding potential and controls the levels
and timing of gene expression. HIV-1 splicing is regulated in part by heterogeneous nuclear …
and timing of gene expression. HIV-1 splicing is regulated in part by heterogeneous nuclear …
A suboptimal 5'splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication
JM Madsen, CM Stoltzfus - Retrovirology, 2006 - Springer
Background Inefficient alternative splicing of the human immunodeficiency virus type 1 (HIV-
1) primary RNA transcript results in greater than half of all viral mRNA remaining unspliced …
1) primary RNA transcript results in greater than half of all viral mRNA remaining unspliced …
Involvement of a Rarely Used Splicing SD2b Site in the Regulation of HIV-1 vif mRNA Production as Revealed by a Growth-Adaptive Mutation
T Koma, N Doi, BQ Le, T Kondo, M Ishizue, C Tokaji… - Viruses, 2023 - mdpi.com
We have previously reported an HIV-1 mutant designated NL-Y226tac that expresses Vif at
an ultra-low level, being replication-defective in high-APOBEC3G cells, such as H9. It carries …
an ultra-low level, being replication-defective in high-APOBEC3G cells, such as H9. It carries …
Characterizing HIV-1 splicing by using next-generation sequencing
A Emery, S Zhou, E Pollom, R Swanstrom - Journal of virology, 2017 - Am Soc Microbiol
Full-length human immunodeficiency virus type 1 (HIV-1) RNA serves as the genome or as
an mRNA, or this RNA undergoes splicing using four donors and 10 acceptors to create over …
an mRNA, or this RNA undergoes splicing using four donors and 10 acceptors to create over …
An exonic splicing silencer downstream of the 3′ splice site A2 is required for efficient human immunodeficiency virus type 1 replication
JM Madsen, CM Stoltzfus - Journal of virology, 2005 - Am Soc Microbiol
Alternative splicing of the human immunodeficiency virus type 1 (HIV-1) genomic mRNA
produces more than 40 unique viral mRNA species, of which more than half remain …
produces more than 40 unique viral mRNA species, of which more than half remain …