High-throughput molecular biology and crystallography advances have placed an
increasing demand on crystallization, the one remaining bottleneck in macromolecular …

Conceptually, protein crystallization can be divided into two phases search and optimization.
Robotic protein crystallization screening can speed up the search phase, and has a …

Protein crystallisation has gained a new strategic and commercial relevance in the post-
genomic era because of its pivotal role in structural genomics. Producing high-quality …

There are five broad areas where noteworthy advances have occurred in the field of
macromolecular crystallization in the past 10 years, though some areas have seen the major …

Introduction: X-ray crystallography provides the majority of our structural biological
knowledge at a molecular level and, in terms of pharmaceutical design, is a valuable tool to …

Advances in genomics have yielded entire genetic sequences for a variety of prokaryotic
and eukaryotic organisms. This accumulating information has escalated the demands for …

The crystallization facility of the TB Structural Genomics Consortium, one of nine NIH-
sponsored structural genomics pilot projects, employs a combinatorial random sampling …

Structural genomics projects have led to great progress in the field of structural biology.
Considerable advances have been made in the automation of all stages of the pipeline from …

Protein structure determination by X-ray crystallography is dependent on obtaining a single
protein crystal suitable for diffraction data collection. Due to this requirement, protein …

Protein crystallization was discovered by chance about 150 years ago and was developed
in the late 19th century as a powerful purification tool and as a demonstration of chemical …