The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

Aims/hypothesis Endothelial cells are considered to be essential for normal pancreatic beta
cell function. However, there have been no reports showing their importance for beta cell …

Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate
blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine …

The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell
types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon …