Comparison of effects induced by toxic applications of kainate and glutamate and by glucose deprivation on area CA1 of rat hippocampal slices

K Alici, T Gloveli, G Weber-Luxenburger, V Motine… - Brain research, 1996 - Elsevier
Baseline and stimulus-induced changes in [Ca2+] o and [K+] o as well as field potentials
(fp's) were studied during application of the excitatory amino acids kainate or glutamate, or …

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

JO Malva, AP Carvalho, CM Carvalho - Neurochemistry international, 1998 - Elsevier
The hippocampal CA3 subregion of the rat is characteristically enriched in kainate receptors.
At the synaptic level, the subcellular localization of these receptors is still a matter of debate …

Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate

K Alici, T Gloveli, D Schmitz, U Heinemann - Neuroscience, 1997 - Elsevier
The functional relevance of presynaptic glutamate receptors in controlling presynaptic Ca2+
influx and thereby transmitter release is unknown. To test if presynaptic Ca2+ entry in the …

A paradox after systemic kainate injection in rats: lesser damage of hippocampal CA1 neurons after higher doses

T Balchen, M Berg, NH Diemer - Neuroscience letters, 1993 - Elsevier
The pyramidal neuron loss in dorsal rat hippocampus was determined 4 days after ip
administration of 10 or 20 mg/kg kainic acid (KA). Histological examination revealed that …

The effect of kainic acid on excitatory synaptic activity in the rat hippocampal slice preparation

GL Collingridge, H McLennan - Neuroscience Letters, 1981 - Elsevier
The effect of iontophoretically applied kainic acid on the response of CA1 neurones to
Schaffer collateral stimulation has been studied in rat hippocampal slices. Brief applications …

Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation

A Schurr, BM Rigor - Brain research, 1993 - Elsevier
The effects of kainate (KA) on the recovery of neuronal function in rat hippocampal slices
after hypoxia or glucose deprivation (GD) were investigated and compared to those of (R, S) …

Role of glutamate receptors and voltage-dependent calcium and sodium channels in the extracellular glutamate/aspartate accumulation and subsequent neuronal …

M Kimura, K Sawada, T Miyagawa, M Kuwada… - … of Pharmacology and …, 1998 - ASPET
Ischemia is believed to induce neuronal damage by causing a sustained increase in the
level of extracellular excitatory amino acids. In our study, we have examined the relationship …

GABAergic neurons are spared after intrahippocampal kainate in the rat

CJ Davenport, WJ Brown, TL Babb - Epilepsy research, 1990 - Elsevier
The present study used Nissl stains and glutamate decarboxylase immunoreactivity (GAD-
IR) to quantify the acute and chronic toxicity of kainic acid (KA) on focal and remote …

Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis

GL Collingridge, SJ Kehl, R Loo… - Experimental brain …, 1983 - Springer
The actions of kainic acid on excitatory synaptic responses in rat hippocampal slices have
been investigated and compared with the effects of other excitatory amino acids. Kainate …

Ion dependence and receptor mediation of glutamate toxicity in the immature rat hippocampal slice

A Lehmann, I Jacobson - European Journal of Neuroscience, 1990 - Wiley Online Library
Glutamate (glu) is a major excitatory transmitter and a toxin in the brain. In the present study,
the immature rat hippocampal slice was used to determine the morphology, topography …