The N-methyl-d-aspartate receptor channel-complex is widely distributed in the
hippocampus, particularly in the CA1 region, in the terminal field of CA3 pyramidal axons …

Hippocampal slices from young (8-day-old) rats were evaluated as a model for investigating
the mechanisms underlying the neurotoxic action of excitatory amino acid receptor agonists …

The intraventricular injection of kainic acid (KA) in rats produces a loss of dentate hilar
neurons and hippocampal CA3 pyramidal cells, and renders the dentate granule cells and …

For the evaluation of glutamatergic and GABAergic transmission during seizures, rat
hippocampal CA1 and CA3 areas were separately assessed by brain microdialysis, and …

We investigated kainate-induced excitotoxicity in embryonic rat hippocampal cells cultured
in a chemically defined medium. Treatment with kainate for 24 h resulted in neuronal death …

Neuron loss, axon sprouting, and the formation of new synaptic circuits have been
hypothesized to contribute to seizures in temporal lobe epilepsy (TLE). Using the kainate …

We investigated the role of kainate (KA) receptor activation and desensitization in inducing
the increase in the intracellular free Ca2+ concentration ([Ca2+] i) in individual cultured rat …

The effects of l-glutamate on the potency of kainate for stimulating guanosine 3', 5'-cyclic
monophosphate (cyclic GMP) accumulation and for killing neurones in incubated slices of …

The effects of the potassium channel openers lemakalim, RP 52891 and galanin and the
potassium channel blockers glibenclamide and gliquidone were evaluated by the release of …

The physiological role of presynaptic glutamate receptors in controlling presynaptic Ca2+-
influx and thereby transmitter release is unknown. To test if presynaptic Ca2+-uptake in the …