Abstract Xiao, HH, Makeyev, Y., Butler, J., Vikram, B. and Franklin, WA 7-
Hydroxystaurosporine (UCN-01) Preferentially Sensitizes Cells with a Disrupted TP53 to …

BACKGROUND & OBJECTIVE: To enhance the radiosensitivity of cancer cell is one of the
most important way to improve the effect of radiotherapy. This study was designed to …

Abstract Mack, PC, Jones, AA, Gustafsson, MH, Gandara, DR, Gumerlock, PH and Goldberg,
Z. Enhancement of Radiation Cytotoxicity by UCN-01 in Non-small Cell Lung Carcinoma …

Abstract 5386 CHK1 kinase is a key regulator of the S and G2 cell cycle checkpoints that are
activated in response to DNA damage. Cell cycle arrest upon DNA damage checkpoint …

PURPOSE: To explore the activity of a potent Chk1 inhibitor (SAR-020106) in combination
with radiation. METHODS AND MATERIALS: Colony and mechanistic in vitro assays and a …

Checkpoint kinase-1 (CHK1) is a key regulator of the DNA damage-elicited G2-M
checkpoints. The aim of the present study was to investigate the effects of a selective CHK1 …

Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the
therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase …

Purpose: Inhibition of checkpoint kinase 1 has been shown to enhance the cytotoxicity of
DNA-damaging targeted chemotherapy through cell cycle checkpoint abrogation and …

Objectives: This study was performed to explore the strategy of combining Chk1 inhibitors
with ionizing radiation (IR) to selectively target p53‐deficient cancer cells. Materials and …

Abstract Wang, XQ, Stanbridge, EJ, Lao, XY, Cai, Q., Fan, ST and Redpath, JL p53-
Dependent Chk1 Phosphorylation is Required for Maintenance of Prolonged G2 Arrest …