[HTML][HTML] Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo
RL Boudreau, I Martins, BL Davidson - Molecular Therapy, 2009 - cell.com
RNA interference (RNAi) provides a promising therapeutic approach to human diseases.
However, data from recent reports demonstrate that short-hairpin RNAs (shRNAs) may …
However, data from recent reports demonstrate that short-hairpin RNAs (shRNAs) may …
The microcosmos of cancer
A Lujambio, SW Lowe - Nature, 2012 - nature.com
The discovery of microRNAs (miRNAs) almost two decades ago established a new
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have …
microRNA functions
N Bushati, SM Cohen - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
microRNAs (miRNAs) are small noncoding RNAs that play important roles in
posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by …
posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by …
MicroRNA silencing through RISC recruitment of eIF6
MicroRNAs (miRNAs) are a class of small RNAs that act post-transcriptionally to regulate
messenger RNA stability and translation. To elucidate how miRNAs mediate their repressive …
messenger RNA stability and translation. To elucidate how miRNAs mediate their repressive …
Selective blockade of microRNA processing by Lin28
SR Viswanathan, GQ Daley, RI Gregory - Science, 2008 - science.org
MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA
expression has been observed in human malignancies. Recent evidence suggests that the …
expression has been observed in human malignancies. Recent evidence suggests that the …
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Therapeutics that are designed to engage RNA interference (RNAi) pathways have the
potential to provide new, major ways of imparting therapy to patients,. Long, double …
potential to provide new, major ways of imparting therapy to patients,. Long, double …
Cloning of short hairpin RNAs for gene knockdown in mammalian cells
PJ Paddison, M Cleary, JM Silva, K Chang, N Sheth… - Nature …, 2004 - nature.com
RNA interference (RNAi) has become a methodology of choice for knocking down gene
expression in a variety of biological systems1, 2. The demonstration, in mammalian in vitro …
expression in a variety of biological systems1, 2. The demonstration, in mammalian in vitro …
IsomiRs: expanding the miRNA repression toolbox beyond the seed
MicroRNAs (miRNAs) are a class of small non-coding RNAs that play increasingly
appreciated roles in gene regulation. In animals, miRNAs silence gene expression by …
appreciated roles in gene regulation. In animals, miRNAs silence gene expression by …
[HTML][HTML] Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
F Ghini, C Rubolino, M Climent, I Simeone… - Nature …, 2018 - nature.com
Little is known about miRNA decay. A target-directed miRNA degradation mechanism
(TDMD) has been suggested, but further investigation on endogenous targets is necessary …
(TDMD) has been suggested, but further investigation on endogenous targets is necessary …
A hexanucleotide element directs microRNA nuclear import
HW Hwang, EA Wentzel, JT Mendell - Science, 2007 - science.org
MicroRNAs (miRNAs) negatively regulate partially complementary target messenger RNAs.
Target selection in animals is dictated primarily by sequences at the miRNA 5′ end. We …
Target selection in animals is dictated primarily by sequences at the miRNA 5′ end. We …