TetX is a flavin-dependent monooxygenase. It has been reported to inactivate all tested
tetracyclines. In this study, Escherichia coli overexpressing TetX was added to soil bacterial …

Tetracyclines are a class of antimicrobials frequently found in the environment, and have
promoted the proliferation of antibiotic resistance. An unanswered research question is …

Inducible gene expression based upon Tet repressor (tet regulation) is a broadly applied
tool in molecular genetics. In its original environment, Tet repressor (TetR) negatively …

Reversible tetracycline-dependent gene regulation allows induction of expression with the
tetracycline repressor (TetR) or gene silencing with the newly developed reverse mutant …

Emergence of pathogens harboring tigecycline resistance genes incurs great concerns.
Wastewater is recognized as the important reservoir of antimicrobial resistance genes. Here …

Tetracyclines are antibiotics commonly used in swine farms to treat disease and promote
growth. However, there are growing concerns regarding the discharge of animal feces into …

Tetracycline (TC) is widely used for prevention and control of animal diseases for its broad
spectrum antimicrobial activity and low cost, but its abuse can seriously affect human health …

Objectives Carbapenems, colistin, and tigecycline are critically important antibiotics in
clinics. After the global appearance of bla NDM and mcr mediating the resistance to …

Background Cannabinoid compounds have been approved as prescription drugs for
treating various human ailments. However, the production using both microbial and plant …

By Northern blot analyses with DNA probes carrying 6-demethylchlortetracycline (6-DCT)
biosynthetic genes from Streptomyces aureofaciens NRRL3203, a highly expressed gene …