[HTML][HTML] Boosting antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in Parkinsonian brain via …

MF Serapide, F L'Episcopo, C Tirolo, N Testa… - Frontiers in Aging …, 2020 - frontiersin.org
Astrocyte (As) bidirectional dialog with neurons plays a fundamental role in major
homeostatic brain functions, particularly providing metabolic support and antioxidant self …

Neural stem cell grafts promote astroglia-driven neurorestoration in the aged parkinsonian brain via Wnt/β-catenin signaling

F L'episcopo, C Tirolo, L Peruzzotti-Jametti… - Stem Cells, 2018 - academic.oup.com
During aging—one the most potent risk factors for Parkinson's disease (PD)—both
astrocytes and microglia undergo functional changes that ultimately hamper homoeostasis …

[HTML][HTML] Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease

B Marchetti - Redox biology, 2020 - Elsevier
Oxidative stress and inflammation have long been recognized to contribute to Parkinson's
disease (PD), a common movement disorder characterized by the selective loss of midbrain …

Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease

F L'Episcopo, C Tirolo, N Testa, S Caniglia… - Stem Cells, 2014 - academic.oup.com
Wnt/β-catenin signaling is required for specification and neurogenesis of midbrain
dopaminergic (mDA) neurons, the pivotal neuronal population that degenerates in …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation

F L'Episcopo, C Tirolo, N Testa, S Caniglia… - Journal of …, 2013 - Soc Neuroscience
Aging and exposure to environmental toxins including MPTP (1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine) are strong risk factors for developing Parkinson's disease (PD), a …

[HTML][HTML] Microglia polarization, gene-environment interactions and Wnt/β-catenin signaling: emerging roles of glia-neuron and glia-stem/neuroprogenitor crosstalk for …

F L'Episcopo, C Tirolo, MF Serapide… - Frontiers in aging …, 2018 - frontiersin.org
Neuroinflammatory processes are recognized key contributory factors in Parkinson's
disease (PD) physiopathology. While the causes responsible for the progressive loss of …

Uncovering novel actors in astrocyte–neuron crosstalk in P arkinson's disease: the W nt/β‐catenin signaling cascade as the common final pathway for neuroprotection …

B Marchetti, F L'Episcopo, MC Morale… - European Journal of …, 2013 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
progressive loss of dopaminergic (DA ergic) neuronal cell bodies in the substantia nigra …

Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease

F L'Episcopo, C Tirolo, S Caniglia… - Journal of molecular …, 2014 - academic.oup.com
During the past three decades, the Wingless-type MMTV integration site (Wnt) signaling
cascade has emerged as an essential system regulating multiple processes in developing …

Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous …

F L'Episcopo, C Tirolo, N Testa, S Caniglia… - Current aging …, 2013 - ingentaconnect.com
Parkinsons' disease (PD), a common neurodegenerative disorder, is characterized by
progressive loss of dopaminergic (DAergic) neurons in the subtantia nigra pars compacta …