Background Regulation in protein networks often utilizes specialized domains
that'join'(or'connect') the network through specific protein-protein interactions. The innate …

Immune systems evolve as essential strategies to maintain homeostasis with the
environment, prevent microbial assault and recycle damaged host tissues. The immune …

It has been speculated that before vertebrates evolved somatic diversity-based adaptive
immunity, the germline-encoded diversity of innate immunity may have been more …

In seeking evidence of the existence of adaptive immune system (AIS) in ancient chordate,
cDNA clones of six libraries from a protochordate, the Chinese amphioxus, were sequenced …

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …

Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of
information about Amphioxus and its evolutionary context. This compilation of what is …

Both amphioxus and the sea urchin encode a complex innate immune gene repertoire in
their genomes, but the composition and mechanisms of their innate immune systems, as …

Unraveling the “code” of genome structure is an important goal of genomics research.
Colocalization of genes in eukaryotic genomes may facilitate preservation of favorable allele …

The origins of the adaptive immune system: whatever next? | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Host–pathogen interactions may result in either directional selection or in pressure for the
maintenance of polymorphism at the molecular level. Hence signatures of both positive and …