Chronic kidney disease–mineral bone disorder (CKD‐MBD) is defined by abnormalities in
mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of …

In chronic kidney disease, vascular calcification, renal osteodystrophy, and phosphate
contribute substantially to cardiovascular risk and are components of CKD–mineral and …

Bone loss and increased fractures are common complications in chronic kidney disease.
Because Wnt pathway activation is essential for normal bone mineralization, we assessed …

The causes of excess cardiovascular mortality associated with chronic kidney disease
(CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD) …

Abstract β-Catenin-dependent canonical Wnt signaling plays an important role in bone
metabolism by controlling differentiation of bone-forming osteoblasts and bone-resorbing …

An association between lower bone mineral density (BMD) and presence of vascular
calcification (VC) has been reported in several studies. Chronic kidney disease (CKD) …

Vascular calcification, bone loss and increased fracture risk are age-associated disorders.
Several epidemiological studies have suggested a relationship between vascular …

It is commonly held that osteitis fibrosa and mixed uremic osteodystrophy are the
predominant forms of renal osteodystrophy in patients with chronic kidney disease. Osteitis …

Chronic Kidney Disease (CKD)–Mineral and Bone Disorder (CKD-MBD) is a complex
disease that is not completely understood. However, some factors secreted by the …

The recent identification of a link between bone mass in humans and gain-or loss-of-function
mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 …