Genomic sequencing of Pleistocene cave bears

JP Noonan, M Hofreiter, D Smith, JR Priest, N Rohland… - Science, 2005 - science.org
Despite the greater information content of genomic DNA, ancient DNA studies have largely
been limited to the amplification of mitochondrial sequences. Here we describe …

Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late pleistocene cave bears

M Hofreiter, C Capelli, M Krings, L Waits… - Molecular Biology …, 2002 - academic.oup.com
Cave bears (Ursus spelaeus) existed in Europe and western Asia until the end of the last
glaciation some 10,000 years ago. To investigate the genetic diversity, population history …

Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments

J Dabney, M Knapp, I Glocke… - Proceedings of the …, 2013 - National Acad Sciences
Although an inverse relationship is expected in ancient DNA samples between the number
of surviving DNA fragments and their length, ancient DNA sequencing libraries are strikingly …

Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments

B Vernot, EI Zavala, A Gómez-Olivencia, Z Jacobs… - Science, 2021 - science.org
INTRODUCTION The study of hominin history has progressed through both archaeological
and genetic insights. Although DNA sequencing from hominin skeletal remains allows the …

Direct multiplex sequencing (DMPS)—a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA

M Stiller, M Knapp, U Stenzel, M Hofreiter… - Genome …, 2009 - genome.cshlp.org
Although the emergence of high-throughput sequencing technologies has enabled whole-
genome sequencing from extinct organisms, little progress has been made in accelerating …

Deciphering the complete mitochondrial genome and phylogeny of the extinct cave bear in the Paleolithic painted cave of Chauvet

C Bon, N Caudy, M De Dieuleveult… - Proceedings of the …, 2008 - National Acad Sciences
Retrieving a large amount of genetic information from extinct species was demonstrated
feasible, but complete mitochondrial genome sequences have only been deciphered for the …

[HTML][HTML] Environmental genomics of Late Pleistocene black bears and giant short-faced bears

MW Pedersen, B De Sanctis, NF Saremi, M Sikora… - Current Biology, 2021 - cell.com
Analysis of ancient environmental DNA (eDNA) has revolutionized our ability to describe
biological communities in space and time, 1–3 by allowing for parallel sequencing of DNA …

[HTML][HTML] Middle Pleistocene genome calibrates a revised evolutionary history of extinct cave bears

A Barlow, JLA Paijmans, F Alberti, B Gasparyan… - Current Biology, 2021 - cell.com
Palaeogenomes provide the potential to study evolutionary processes in real time, but this
potential is limited by our ability to recover genetic data over extended timescales. 1 As a …

Whole-genome shotgun sequencing of mitochondria from ancient hair shafts

MTP Gilbert, LP Tomsho, S Rendulic, M Packard… - science, 2007 - science.org
Although the application of sequencing-by-synthesis techniques to DNA extracted from
bones has revolutionized the study of ancient DNA, it has been plagued by large fractions of …

[HTML][HTML] Ancient DNA analysis reveals divergence of the cave bear, Ursus spelaeus, and brown bear, Ursus arctos, lineages

O Loreille, L Orlando, M Patou-Mathis, M Philippe… - Current Biology, 2001 - cell.com
The cave bear, Ursus spelaeus, represents one of the most frequently found paleontological
remains from the Pleistocene in Europe. The species has always been confined to Europe …