For the first time there is now clear biochemical and biophysical evidence indicating that
members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family …

Intracellular NOD-like receptor (NLR) proteins are believed to play important roles in innate
immune detection or immune regulation, but only a few NLR proteins are functionally …

Innate immunity is a primary defense system against microbial infections. Innate immune
pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens …

Luciferase reporter assays (LRAs) are widely used to assess the activity of specific signal
transduction pathways. Although powerful, rapid and convenient, this technique can also …

NOD-like receptors (NLRs) are pattern recognition receptors for diverse innate immune
responses. Self-oligomerization after engagement with a ligand is a generally accepted …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Members of the Nod-like receptor (NLR) family recognize intracellular pathogens and recruit
a variety of effector molecules, including pro-caspases and kinases, which in turn are …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

The last 10 years have witnessed the identification of a new class of intracellular pattern-
recognition molecules—the nucleotide-binding domain and leucine-rich repeat–containing …

NOD-like receptors represent an important class of germline-encoded pattern recognition
receptors that play key roles in the regulation of inflammatory signalling pathways. They …