Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Although prostate cancer (PCa) is the second leading cause of cancer death among men
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …

The prostate gland is the most common site of cancer and the second leading cause of
cancer death in American men. Recent emerging molecular biological technologies help us …

Background DNA methylation has been linked to genome regulation and dysregulation in
health and disease respectively, and methods for characterizing genomic DNA methylation …

BACKGROUND DNA hypermethylation has emerged as a novel molecular biomarker for the
evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene …

Prostate cancer is the most common malignancy and the second leading cause of cancer
death among men in the United States. There are three well-established risk factors for …

Background Promoter and 5′ end methylation regulation of tumour suppressor genes is a
common feature of many cancers. Such occurrences often lead to the silencing of these key …

Increasing evidence suggests that aberrant DNA methylation changes may contribute to
prostate cancer (PCa) ethnic disparity. To comprehensively identify DNA methylation …