It has been reported that 5-HT7 receptors are promising targets of depression and
neuropathic pain. 5-HT7 receptor antagonists have exhibited antidepressant-like profiles …

We previously demonstrated that 20 (S)-ginsenoside Rg3 (Rg3), one of the active
components of Panax ginseng, non-competitively inhibits 5-HT3A receptor channel activity …

Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel
extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a …

抄録 It has been reported that an acetone extract of ginger and its fractions have anti-5-HT (5-
hydroxytryptamine; serotonin) effects. In the present study, guinea pig ileum, rat stomach …

Novel conformationally constrained derivatives of classical 5-HT3 receptor antagonists were
designed and synthesized with the aim of probing the central 5-HT3 receptor recognition site …

Obesity prevalence continues to be a foremost health concern across the globe leading to
the development of major health risk conditions like type II diabetes, hyperlipidemia …

A series of compounds with quinazoline scaffold were designed, synthesized and evaluated
as novel potent 5-HT 2A receptor ligands. N-(4-Chlorophenyl)-2-(piperazin-1-yl) quinazolin …

We have previously reported that dual 5-HT 1A and 5-HT 7 receptor ligands might find utility
as treatment options for various CNS related conditions including cognitive and anxiolytic …

A focused SAR study around the previously reported selective 5-HT7 receptor antagonist,
SB-269970-A has resulted in the identification of a structurally related analogue having an …

5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the
involvement of the 5-HT7 receptor in other pathophysiological mechanisms such as …