5-HT3A receptor antagonists have been used mainly for the treatment of nausea and
vomiting. These days, the antagonists are of special interest due to their therapeutic …

The involvement of the neurotransmitter serotonin (5-HT) in numerous physiological
functions is often attributed to the diversity of receptors with which it interacts. Ligands …

The current study is focused on newly developed phenylpiperazine derivatives of aromatic
methylhydantoin differing in mutual positions of methyl and phenyl moieties. The new …

AIM OF THE STUDY: Poncirus fructus (PF)–also known as the dried, immature fruit of
Poncirus trifoliata (L.) Raf.(Rutaceae)–is a natural substance that has long been used for …

A series of compounds with quinazoline scaffold were designed, synthesized and evaluated
as novel potent 5-HT 2A receptor ligands. N-(4-Chlorophenyl)-2-(piperazin-1-yl) quinazolin …

Novel arene-and quinolinesulfonamides were synthesized using different solutions and a
solid-support methodology, and were evaluated for their affinity for 5-HT1A, 5-HT2A, 5-HT6 …

A 5‐HT3 receptor agonist based on a benzamide scaffold was identified in a screening of a
small commercial compound library, and an elaborate SAR study originating from this hit …

A series of novel 6-fluorochroman derivatives was prepared and evaluated as antagonists
for the 5-HT1A receptor. N-2-[[(6-Fluorochroman-8-yl) oxy] ethyl]-4-(4-methoxyphenyl) …

Peppermint oil (Mentha× piperita L.(Lamiaceae) has been shown to exert potent antiemetic
properties, but its mode of action has not yet been elucidated. Among its active constituents …

Xenopus oocytes and found that 20 (S)-Rg3 rather than 20 (R)-Rg3 was more stronger
inhibitor of I5-HT. In the present study, we further investigated the effects of 20 (R)-Rg3 and …