Xenopus oocytes and found that 20 (S)-Rg3 rather than 20 (R)-Rg3 was more stronger
inhibitor of I5-HT. In the present study, we further investigated the effects of 20 (R)-Rg3 and …

Poria cocos Wolf (P. cocos Wolf) is used to treat chronic gastritis, edema, nephrosis, gastric
atony, acute gastroenteric catarrh, dizziness, emesis and vomiting. Triterpenoids are a class …

Gingerols and shogaols are the primary non-volatile actives within ginger (Zingiber
officinale). These compounds have demonstrated in vitro to exert 5-HT 3 receptor …

5-Methoxy-N, N-dimethyltryptamine (1) and N, N-dimethyltryptamine (2) isolated from the
dried, unripe fruit of Evodia rutaecarpa interacted with 5-HT1A receptors with K i values of 28 …

In previous structure–activity relationship studies to identify new and selective 5‐HT7
receptor (5‐HT7R) ligands, we identified the chiral compound, 5‐chloro‐2‐{2‐[3, 4 …

Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

The modulation by K+ channel-acting drugs of the antinociceptive effect of several 5-HT1A
receptor agonists was examined with the hot plate test in mice. All the 5-HT1A receptor …

The well-known 5-HT1A/5-HT7 selectivity issue was tackled by a new series of 4-
aminoethylpiperazinyl aryl ketones (1a–1l) specifically designed to distinguish the two …

The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor
antagonist. The compound was synthesized in seven steps starting from indolineand …

GYKI-46903 [(+)-(5 s, 6r)-4-(4-fluorophenyl)-6-propionyloxy-1-aza-bicyclo [3.3. 1]-non-3-ene-
hy-drochloride], a cognition enhancer identified as a non-competitive antagonist of 5 …